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Novexin Gen innovative technologies and products provide dramatic improvements in the handling and analysis of proteins in solution.

NVoy technology uses novel NV polymers which can enhance protein stability, solubility, purification, analysis and storage in research and commercial use.

Novexin's technology has also been applied to existing formulations to give improved products in protein assay and detection.

Enabling Protein Science Expression Greater use of high expressing, cost efficient and effective E. coli Aggregation Control Suppresses aggregation effectively, controlled release mechanism. Refolding Generic, improved yields, rapid yes/no answer for refolding success Analysis Reagents compatible with common techs, higher protein concentrations used Purification Easy to remove reagents, no detergents used Stability Maintain monomeric protein, usable liquid stock with no freeze/thaw and no lyophilising Crystallisation Enables working with higher protein concentrations and keeps proteins soluble Storage Concentrated stock solutions at 4°C Production Seamless transfer research to production, reduced time and labour Product Spotlight Stabil-P·A·C Stabil-P·A·C contains a specific formulation of proprietary NV polymers that suppresses aggregation and keeps proteins soluble without affecting protein structure and enabling analysis via CD, mass spectrometry and NMR.

NVoy technology using novel NV polymers, stabilises and solubilises proteins enabling their purification, analysis and storage in research and in production.

Novexin's technology has also been applied to existing formulations to give improved products in protein assay and detection.

Technology overview NVoy Common Uses Protein Solubility and Stability Special Offers New Customers Bradford ULTRA - Designed to detect total protein in the presence of detergents. What's New Using NV polymer Tag Cleavage NV polymer can protect proteins from aggregation and loss of yield after tag cleavage.

Crystallography NVoy technology protects protein at high concentration and promotes protein crystal growth.

Protein stabilisation Improve protein standards stability.

Concentrating Proteins NV polymer improves protein recovery upon concentration.

Protein recovery after dialysis NV polymer protects proteins from aggregation and loss to membranes during dialysis.

Novexin's NVoy technology is a quantum leap in protein processing, production and analysis as our polymers enhance protein solubility and stability through the formation of multi-point reversible complexes with proteins without altering their structure.
NVoy offers an alternative to the use of detergents, fusion proteins, chaperones and the myriad of other techniques employed to surmount the problems posed by manipulating proteins, enzymes and antibodies in solution. Its generic nature allows it to be applied throughout the whole protein production process.
NVoy employs NV molecules (≡NV polymers) which are linear carbohydrate polymers of ∼5KD. Our chemistry modification gives the polymers a hydrophobic face, making them extremely amphipathic.
The inherent characteristics of these NV molecules enables them to associate with proteins via a Velcro-like effect—“multipoint binding”—and this allows the reversible formation of the NV-Protein complexes without disruption of the protein structure.
Proteins are therefore protected and stabilised against aggregation enabling the processing of difficult to handle proteins at high concentrations under conditions that would usually result in the formation of useless aggregates.
This offers multiple benefits for protein processing and production, particularly in the area’s of protein refolding, stabilisation, purification, analysis and crystallisation.